Mapping Bone Changes at the Proximal Femoral Cortex of Postmenopausal Women in Response to Alendronate and Teriparatide Alone, Combined or Sequentially

ABSTRACT Combining antiresorptive and anabolic drugs for osteoporosis may be a useful strategy to prevent hip fractures. Previous studies comparing the effects of alendronate (ALN) and teriparatide (TPTD) alone, combined or sequentially using quantitative computed tomography (QCT) in postmenopausal...

Full description

Saved in:
Bibliographic Details
Published in:Journal of bone and mineral research 2015-07, Vol.30 (7), p.1309-1318
Main Authors: Whitmarsh, Tristan, Treece, Graham M, Gee, Andrew H, Poole, Kenneth ES
Format: Article
Language:English
Subjects:
Aged
ALENDRONATE
Alendronate - pharmacology
BMD
CORTICAL THICKNESS
Drug Therapy, Combination
Female
Femur - drug effects
Humans
Middle Aged
OSTEOPOROSIS
Postmenopause - drug effects
QCT
TERIPARATIDE
Teriparatide - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Combining antiresorptive and anabolic drugs for osteoporosis may be a useful strategy to prevent hip fractures. Previous studies comparing the effects of alendronate (ALN) and teriparatide (TPTD) alone, combined or sequentially using quantitative computed tomography (QCT) in postmenopausal women have not distinguished cortical bone mineral density (CBMD) from cortical thickness (CTh) effects, nor assessed the distribution and extent of more localized changes. In this study a validated bone mapping technique was used to examine the cortical and endocortical trabecular changes in the proximal femur resulting from an 18‐month course of ALN or TPTD. Using QCT data from a different clinical trial, the global and localized changes seen following a switch to TPTD after an 18‐month ALN treatment or adding TPTD to the ALN treatment were compared. Ct.Th increased (4.8%, p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.2454