Efficacy of different modes of fractional CO2 laser in the treatment of primary cutaneous amyloidosis: A randomized clinical trial

• Published in: Lasers in surgery and medicine 2015-07, Vol.47 (5), p.388-395
• Main Authors: Esmat, Samia M., Fawzi, Marwa M., Gawdat, Heba I., Ali, Heba S., Sayed, Safinaz S.
• Format: Article
• Language: English
• Subjects: Adult; Amyloidosis, Familial - pathology; Amyloidosis, Familial - surgery; Deep rejuvenation; Female; Fractional CO2; Humans; Laser Therapy - methods; Lasers, Gas - therapeutic use; Male; Middle Aged; Patient Satisfaction; Primary cutaneous amyloidosis; Prospective Studies; Single-Blind Method; Skin Diseases, Genetic - pathology; Skin Diseases, Genetic - surgery; Superficial ablation; Treatment Outcome; Young Adult
• ISSN: 0196-8092; 1096-9101
• DOI: 10.1002/lsm.22361

Background Primary cutaneous amyloidosis (PCA) comprises three main forms: macular, lichen, and nodular amyloidosis. The current available treatments are quite disappointing. Objectives Assess and compare the clinical and histological changes induced by different modes of Fractional CO2 laser in treatment of PCA. Patients and Methods Twenty five patients with PCA (16 macular and 9 lichen amyloidosis) were treated by fractional CO2 using; superficial ablation (area A) and deep rejuvenation (area B). Each patient received 4 sessions with 4 weeks intervals. Skin biopsies were obtained from all patients at baseline and one month after the last session. Patients were assessed clinically and histologically (Congo red staining, polarized light). Patients were followed‐up for 3 months after treatment. Results Both modes yielded significant reduction of pigmentation, thickness, itching, and amyloid deposits (P‐value