Cancer-like metabolism of the mammalian retina

The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the Warburg effect. In recent years, the Warburg effect has become an explosive area of study within the cancer research community. The exp...

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Bibliographic Details
Published in:Clinical & experimental ophthalmology 2015-05, Vol.43 (4), p.367-376
Main Authors: Ng, Soo Khai, Wood, John PM, Chidlow, Glyn, Han, Guoge, Kittipassorn, Thaksaon, Peet, Daniel J, Casson, Robert J
Format: Article
Language:English
Subjects:
aerobic glycolysis
Animals
Cancer
Energy Metabolism - physiology
Glycolysis - physiology
HIF-1
Humans
mammalian retina
Metabolism
Neoplasms - metabolism
Oxidative Phosphorylation
Oxygen - physiology
PKM2
Pyruvate Kinase - metabolism
Retina
Retina - metabolism
Warburg effect
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Summary:The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the Warburg effect. In recent years, the Warburg effect has become an explosive area of study within the cancer research community. The expanding knowledge about the molecular mechanisms underpinning the Warburg effect in cancer promises to provide a greater understanding of mammalian retinal metabolism and has motivated cancer researchers to target the Warburg effect as a novel treatment strategy for cancer. However, if the molecular mechanisms underlying the Warburg effect are shared by the retina and cancer, treatments targeting the Warburg effect may have serious adverse effects on retinal metabolism. Herein, we provide an updated understanding of the Warburg effect in mammalian retina.
ISSN:1442-6404
1442-9071
DOI:10.1111/ceo.12462