Use of first or second trimester serum markers, or both, to predict preeclampsia

Highlights • Longitudinal study of serum markers and preeclampsia (PE) in early pregnancy. • Strongest association found for 2nd trimester markers and severe/early PE. • Pregnancy-associated plasma protein-A (PAPP-A) strongest marker for PE. • Placental like growth factor (PlGF) strongest late marke...

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Bibliographic Details
Published in:Pregnancy hypertension 2014-10, Vol.4 (4), p.271-278
Main Authors: Lambert-Messerlian, Geralyn, Eklund, Elizabeth E, Chien, Edward K, Rosene-Montella, Karen, Neveux, Louis M, Haddow, Hamish R.M, Palomaki, Glenn E
Format: Article
Language:English
Subjects:
Cardiovascular
Endoglin
Inhibin A
Obstetrics and Gynecology
PAPP-A
PlGF
Preeclampsia
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Summary:Highlights • Longitudinal study of serum markers and preeclampsia (PE) in early pregnancy. • Strongest association found for 2nd trimester markers and severe/early PE. • Pregnancy-associated plasma protein-A (PAPP-A) strongest marker for PE. • Placental like growth factor (PlGF) strongest late marker for severe/early PE. • No markers were suitable for a between-trimester repeated measure.
ISSN:2210-7789
2210-7797
DOI:10.1016/j.preghy.2014.07.001