Vestibular effects of lidocaine intratympanic injection in rats

When lidocaine is locally delivered into the inner ear, it rapidly paralyzes the peripheral vestibular afferent neurons and induces unilateral vestibular loss. The goals of this study were to explore the possibility of developing intratympanic injection (IT) of lidocaine as a modality for treating a...

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Bibliographic Details
Published in:Human & experimental toxicology 2014-11, Vol.33 (11), p.1121-1133
Main Authors: Lee, HH, Kim, MJ, Jo, YK, Kim, JY, Han, GC
Format: Article
Language:English
Subjects:
Anesthetics, Local - administration & dosage
Anesthetics, Local - adverse effects
Animals
Biological and medical sciences
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Female
Injections
Lidocaine - administration & dosage
Lidocaine - adverse effects
Medical sciences
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Non tumoral diseases
Nystagmus, Pathologic - chemically induced
Oculomotor disorders
Ophthalmology
Otorhinolaryngology. Stomatology
Pharmacology
Rats, Sprague-Dawley
Rodents
Toxicity
Toxicology
Tympanic Membrane
Vertigo
Vertigo - drug therapy
Vestibule, Labyrinth - drug effects
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Summary:When lidocaine is locally delivered into the inner ear, it rapidly paralyzes the peripheral vestibular afferent neurons and induces unilateral vestibular loss. The goals of this study were to explore the possibility of developing intratympanic injection (IT) of lidocaine as a modality for treating acute vertigo. To evaluate the minimum concentration required, latent time, action duration, and possibility of lidocaine IT readministration to the vestibular system, we compared the development of horizontal nystagmus after IT of 2, 4, 6, 8, and 10% lidocaine solutions in rats. To identify the induction of vestibular compensation, c-Fos-like protein expression was observed in the vestibular nucleus. Results of our investigation showed that lidocaine IT concentrations greater than 4% induced vestibular hyporeflexia in the injected ear. In order to induce hyporeflexia 4 and 6% lidocaine solutions could also be repeatedly injected. Regardless of concentration, effects of the lidocaine IT dissipated gradually over time. Our findings could be used to develop novel methods for symptom control in vestibular disorder patients.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327113515501