Soudanones A–G: Antifungal Isochromanones from the Ascomycetous Fungus Cadophora sp. Isolated from an Iron Mine

One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A–G, 3–9), and six known analogues including 10 and 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2 M, collected from the subterranean 10th level of the Soudan Underground Iron Mine in Minnesota. All...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2015-06, Vol.78 (6), p.1456-1460
Main Authors: Rusman, Yudi, Held, Benjamin W, Blanchette, Robert A, Wittlin, Sergio, Salomon, Christine E
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Candida albicans - drug effects
Chromans
Chromones - chemistry
Chromones - isolation & purification
Chromones - pharmacology
Cryptococcus neoformans - drug effects
Iron
Microbial Sensitivity Tests
Mining
Minnesota
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
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Summary:One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A–G, 3–9), and six known analogues including 10 and 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2 M, collected from the subterranean 10th level of the Soudan Underground Iron Mine in Minnesota. All of the compounds were tested against a panel of microbial pathogens, and 2, 3, 10, and 11 were found to have activity against Cryptococcus neoformans (MIC = 35, 40, 20, and 30 μg/mL, respectively). Compound 11 was also active against Candida albicans, with an MIC of 40 μg/mL.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.5b00204