Multifraction radiotherapy for palliation of painful bone metastases: 20 Gy versus 30 Gy

• Published in: Tumori 2015-05, Vol.101 (3), p.318-322
• Main Authors: Valeriani, Maurizio, Scaringi, Claudia, Blasi, Luciana, Carnevale, Alessia, De Sanctis, Vitaliana, Bonome, Paolo, Bracci, Stefano, Marrone, Gianluca, Minniti, Giuseppe, Enrici, Riccardo Maurizi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Bone Neoplasms - complications; Bone Neoplasms - radiotherapy; Bone Neoplasms - secondary; Chi-Square Distribution; Dose Fractionation; Female; Fractures, Spontaneous - complications; Fractures, Spontaneous - etiology; Humans; Logistic Models; Male; Middle Aged; Pain - etiology; Pain Management - methods; Pain Measurement; Palliative Care - methods; Radiotherapy Dosage; Retrospective Studies; Treatment Outcome
• ISSN: 0300-8916; 2038-2529
• DOI: 10.5301/tj.5000286

To compare 2 multifraction radiotherapy schedules in the palliation of painful bone metastases. We retrospectively analyzed clinical data of 105 patients with a total of 140 painful bone metastases who were treated with 20 Gy in 5 fractions or 30 Gy in 10 fractions. The primary tumors were breast (30%), lung (28%), and prostate (14%). The main sites of irradiation were spine (n = 79) and sacrum or pelvis (n = 39). Pain was graded by patients according to the pain numeric rating scale just before and 1 month after radiotherapy. Pain progression was defined as an increase ≥2 on pain scale after an initial response. The overall response rate at 1 month was 88.6%. Overall response rate was 89.6% in the 20-Gy arm and 87.3% in the 30-Gy arm (p = 0.669). The rate of complete response was statistically better in patients treated with 30 Gy (p = 0.019). The mean reduction in pain was 3.2 in the 20-Gy group and 3.6 in the 30-Gy group. Pain progression was 6.5% and 1.6%, respectively. The incidence of acute toxicity was statistically significantly higher in the 30-Gy arm (23.8%) than in the 20-Gy arm (2.6%) (p = 0.001). One pathologic fracture of the irradiated bone was observed in the 30-Gy arm. Two lesions, one in each group, were re-irradiated for pain recurrence. Pain progression was found in 6.5% of the irradiated lesions in the 20-Gy arm and in 1.6% in the 30-Gy arm. In our series, both regimens achieved high rate of pain relief, although the group treated with higher total dose reported better complete response rate. The 30-Gy arm had a significantly higher rate of acute toxicity.