Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

Abstract Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation (AF) while AF is a strong and independent marker of overall mortality and cardiovascular morbidity in diabetic patients. Autonomic, electrical, electromechanical, and structural remodeling, incl...

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Bibliographic Details
Published in:International journal of cardiology 2015-04, Vol.184, p.617-622
Main Authors: Goudis, Christos A, Korantzopoulos, Panagiotis, Ntalas, Ioannis V, Kallergis, Eleftherios M, Liu, Tong, Ketikoglou, Dimitrios G
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Antioxidants - therapeutic use
Atrial fibrillation
Atrial Fibrillation - metabolism
Atrial Fibrillation - physiopathology
Atrial Fibrillation - therapy
Atrial remodeling
Cardiovascular
Diabetes mellitus
Diabetes Mellitus - metabolism
Diabetes Mellitus - physiopathology
Diabetes Mellitus - therapy
Humans
Oxidative Stress - physiology
Risk Factors
Upstream therapies
Ventricular Remodeling - physiology
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Summary:Abstract Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation (AF) while AF is a strong and independent marker of overall mortality and cardiovascular morbidity in diabetic patients. Autonomic, electrical, electromechanical, and structural remodeling, including oxidative stress, connexin remodeling and glycemic fluctuations seem to be implicated in AF pathophysiology in the setting of DM. The present review highlights the association between DM and AF, provides a comprehensive overview of the responsible pathophysiological mechanisms and briefly discusses potential upstream therapies for DM-related atrial remodeling.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2015.03.052