Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives

Abstract Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antib...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cardiology 2015-04, Vol.184, p.244-250
Main Authors: Santos-Pardo, Irene, Villuendas, Roger, Salvador-Corres, Iñaki, Martínez-Morillo, Melania, Olivé, Alejandro, Bayes-Genis, Antoni
Format: Article
Language:English
Subjects:
Anti-Ro/SSA
Arrhythmias, Cardiac - blood
Arrhythmias, Cardiac - diagnosis
Arrhythmias, Cardiac - immunology
Autoantibodies - blood
Biomarkers - blood
Cardiac rhythm disturbances
Cardiovascular
Case-Control Studies
Forecasting
Humans
Pathogenesis
Retrospective Studies
Ribonucleoproteins - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2014.11.002