Syndecan-1 in Acute Decompensated Heart Failure　– Association With Renal Function and Mortality

Background:Heart failure (HF) is a leading cause of hospitalization throughout the world, and the mortality rate remains elevated. HF is frequently complicated by acute kidney injury (AKI), worsening the patient’s prognosis. There have been no studies evaluating the role that endothelial glycocalyx...

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Bibliographic Details
Published in:Circulation Journal 2015/06/25, Vol.79(7), pp.1511-1519
Main Authors: Fernanda Macedo de Oliveira Neves, Meneses, Gdayllon Cavalcante, Sousa, Nazareth Ermínia Araujo, Ramon Róseo Paula Pessoa Bezerra de Menezes, Parahyba, Marcelo Coelho, Martins, Alice Maria Costa, Libório, Alexandre Braga
Format: Article
Language:English
Subjects:
Acute Disease
Acute kidney injury
Acute Kidney Injury - blood
Acute Kidney Injury - etiology
Acute Kidney Injury - mortality
Aged
Biomarkers - blood
Brazil
Emergency Service, Hospital
Endothelial function
Female
Follow-Up Studies
Heart failure
Heart Failure - blood
Heart Failure - complications
Heart Failure - mortality
Hospital Mortality
Humans
Kidney - metabolism
Male
Middle Aged
Syndecan-1
Syndecan-1 - blood
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Summary:Background:Heart failure (HF) is a leading cause of hospitalization throughout the world, and the mortality rate remains elevated. HF is frequently complicated by acute kidney injury (AKI), worsening the patient’s prognosis. There have been no studies evaluating the role that endothelial glycocalyx damage plays in HF patients and its association with AKI and mortality.Methods and Results:We measured several endothelial biomarkers in 201 consecutive patients with acute decompensated HF (ADHF) during emergency department (ED) admission. In-hospital mortality, AKI development and 6-month mortality rates were assessed. ADHF patients with worsening renal function had higher levels of syndecan-1 but not those patients with stable chronic kidney disease. Syndecan-1 levels during ED admission were predictive for AKI during the hospital stay (AUC 0.741, P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-14-1195