Comparison of tissue trauma after abdominal, vaginal and total laparoscopic hysterectomy

The aim of the study was to compare the extent of tissue trauma atter abdominal hysterectomy(AH), vaginal hysterectomy (VH), and total laparoscopic hysterectomy (TLH) using biochemical markers. Seventy-one patients requiring hysterectomy for benign uterine diseases were enrolled in the study and div...

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Bibliographic Details
Published in:Ginekologia polska 2015-01, Vol.86 (4), p.268-273
Main Authors: Oksuzoglu, Aysegul, Seckin, Berna, Turkcapar, Ayse Figen, Ozcan, Sarp, Gungor, Tayfun
Format: Article
Language:English
Subjects:
Adult
Creatine Kinase - blood
Female
Humans
Hysterectomy
Hysterectomy - adverse effects
Interleukin-6 - blood
Laparoscopy
Laparoscopy - adverse effects
Middle Aged
Soft Tissue Injuries - immunology
Stress, Physiological - immunology
Uterine Neoplasms - surgery
Vagina
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Summary:The aim of the study was to compare the extent of tissue trauma atter abdominal hysterectomy(AH), vaginal hysterectomy (VH), and total laparoscopic hysterectomy (TLH) using biochemical markers. Seventy-one patients requiring hysterectomy for benign uterine diseases were enrolled in the study and divided into three treatment groups: AH (n=24), VH (n=23), and TLH (n=24). Blood samples for assay of interleukin-6 (IL-6) and creatine phosphokinase (CPK) were collected pre-, intra-operatively and 2, 6 and 24 h after surgery. Serum levels of IL-6, and CPK were significantly elevated over basal values after surgery in all groups. IL-6 and CPK levels were significantly higher after AH as compared to VH and TLH. IL-6 concentrations were significantly higher in the VH group than the TLH group (p=0.00 1). There were no significant differences in CPK levels between the VH and TLH groups (p=0.824). TLH group had the smallest decrease in blood hemoglobin concentration and the shortest hospital stay AH causes more tissue trauma as compared to VH and TLH. Owing to the fact that TLH is associated with less tissue trauma and offers significant clinical benefits, including less blood loss and shorter hospital stay it should be considered in women with benign gynecologic conditions, especially in experienced centers.
ISSN:0017-0011
2543-6767
DOI:10.17772/gp/2072