Coherent Anti-Stokes Raman Scattering Microspectroscopic Kinetic Study of Fast Hydrogen Bond Formation in Microfluidic Devices

The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer r...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2013-10, Vol.85 (19), p.8923-8927
Main Authors: Oshovsky, Gennady V, Rago, Gianluca, Day, James P. R, Soudijn, Maarten L, Rock, William, Parekh, Sapun H, Ciancaleoni, Gianluca, Reek, Joost N. H, Bonn, Mischa
Format: Article
Language:English
Subjects:
Bonding
Chemical compounds
Coherent scattering
Devices
Formations
Hydrogen Bonding
Hydrogen bonds
Kinetics
Microfluidic Analytical Techniques
Microfluidics
Molecular Structure
Propanols - chemistry
Pyridines - chemistry
Raman scattering
Reaction kinetics
Scattering
Spectrum analysis
Spectrum Analysis, Raman
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Summary:The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer resolution. Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine–hexafluoroisopropanol hydrogen bonded complex in dichloromethane-d 2 were determined to be k 1 > 105 M–1s–1 and k –1 > 333.3 s–1, respectively.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac402233n