Synthesis and self-assembly of amphiphilic poly(acrylicacid)–poly(ɛ-caprolactone)–poly(acrylicacid) block copolymer as novel carrier for 7-ethyl-10-hydroxy camptothecin

The process of molecular self-assembly plays a crucial role in formulation of polymeric nanoparticulated drug delivery carriers as it creates the possibility for enhanced drug encapsulation and carrier surface engineering. This study aimed to develop a novel self-assembled polymeric micelles for tar...

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Bibliographic Details
Published in:Journal of biomaterials applications 2015-01, Vol.29 (6), p.867-881
Main Authors: Djurdjic, Beti, Dimchevska, Simona, Geskovski, Nikola, Petrusevska, Marija, Gancheva, Valerya, Georgiev, Georgi, Petrov, Petar, Goracinova, Katerina
Format: Article
Language:English
Subjects:
Absorption, Physicochemical
Acrylic Resins - adverse effects
Acrylic Resins - chemistry
Adenocarcinoma - drug therapy
Adenocarcinoma - pathology
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Camptothecin - administration & dosage
Camptothecin - adverse effects
Camptothecin - analogs & derivatives
Camptothecin - chemistry
Carriers
Cell Line, Tumor
Cell Survival - drug effects
Delayed-Action Preparations - adverse effects
Delayed-Action Preparations - chemistry
Diffusion
Drug delivery systems
Drugs
Encapsulation
Formulations
Fragmentation
Humans
Materials Testing
Micelles
Nanocapsules - adverse effects
Nanocapsules - chemistry
Nanocapsules - ultrastructure
Nanostructure
Particle Size
Polyesters - adverse effects
Polyesters - chemistry
Self assembly
Treatment Outcome
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Summary:The process of molecular self-assembly plays a crucial role in formulation of polymeric nanoparticulated drug delivery carriers as it creates the possibility for enhanced drug encapsulation and carrier surface engineering. This study aimed to develop a novel self-assembled polymeric micelles for targeted delivery in tumor cells in order to overcome not only various drawbacks of 7-ethyl-10-hydroxy camptothecin (SN-38) but also various reported limitations of other drug delivery systems, especially low drug loading and premature release. Custom synthesized amphiphilic triblock copolymer poly(acrylic acid)–poly(ɛ-caprolactone)–poly(acrylic acid) (PAA13–PCL35–PAA13) was used to prepare kinetically stable micelles by nanoprecipitation and modified nanoprecipitation procedure. Core-shell micelles with diameter of 120–140 nm, negative zeta potential and satisfactory drug loading were produced. The prepared formulations were stable in pH range of 3–12 and in media with NaCl concentration
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328214549612