Structural properties of silver doped hydroxyapatite and their biocompatibility

The aim of this study was to obtain a novel hydroxyapatite-based material with high biocompatibility. The structural properties of the samples were well characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray Photoelectron Spectroscopy (XPS). The X-ray diffraction stud...

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Bibliographic Details
Published in:Materials Science & Engineering C 2013-04, Vol.33 (3), p.1395-1402
Main Authors: Ciobanu, C.S., Iconaru, S.L., Pasuk, I., Vasile, B.S., Lupu, A.R., Hermenean, A., Dinischiotu, A., Predoi, D.
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Calcium - analysis
Escherichia coli - drug effects
Homogeneity
Hydroxyapatite
Hydroxyapatites - chemistry
Macrophage
Macrophages - cytology
Macrophages - drug effects
Materials Testing
Mice
Microbial Sensitivity Tests
Microscopy, Electron, Transmission
Nitric oxide
Phases
Photoelectron Spectroscopy
Scanning electron microscopy
Silver
Silver - analysis
Silver - chemistry
Spectrometry, X-Ray Emission
Spectroscopy, Fourier Transform Infrared
Surface chemistry
X-Ray Diffraction
X-ray photoelectron spectroscopy
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Summary:The aim of this study was to obtain a novel hydroxyapatite-based material with high biocompatibility. The structural properties of the samples were well characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray Photoelectron Spectroscopy (XPS). The X-ray diffraction studies revealed the characteristic peaks of hydroxyapatite in each sample. Other phases or impurities were not observed. The scanning electron microscopy observations suggest that the doping components have no influence on the surface morphology of the samples, which reveals a homogeneous aspect of the synthesized particles for all samples. The presence of calcium (Ca), phosphor (P), oxygen (O) and silver (Ag) in the Ag:HAp is confirmed by energy dispersive X-ray (EDAX) and X-ray Photoelectron Spectroscopy analyses. Nanocrystalline silver doped HAp stimulated viability and potentiated the activation of murine macrophages. ► A simple and low cost methodology to obtain Ag:HAp powders was described in this paper. ► Nanocrystalline Ag:HAp with different xAg from can be obtained at 100 °C by co-precipitation. ► The study aims to understand the effects of Ag:HAp NPs with different xAg on macrophage cells.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2012.12.042