Novel highly sensitive Cu-based SERS platforms for biosensing applications

Novel surface enhanced Raman spectroscopy (SERS) platforms have been prepared and used for the bacteria detection. Unlike typical, expensive SERS platforms prepared from gold or silver, the presented platforms are prepared using copper. A new, simple, cost‐efficient and fast high pressure method is...

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Bibliographic Details
Published in:Journal of Raman spectroscopy 2015-05, Vol.46 (5), p.428-433
Main Authors: Kowalska, Aneta Aniela, Kaminska, Agnieszka, Adamkiewicz, Witold, Witkowska, Evelin, Tkacz, Marek
Format: Article
Language:English
Subjects:
APPLICATIONS
Bacteria
Copper
copper-based surfaces
enhancement factors
Gold
high pressure methods
MATHEMATICAL ANALYSIS
MEDICINE
Platforms
Raman spectroscopy
Silver
Staphylococcus aureus
surface enhanced Raman spectroscopy
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Summary:Novel surface enhanced Raman spectroscopy (SERS) platforms have been prepared and used for the bacteria detection. Unlike typical, expensive SERS platforms prepared from gold or silver, the presented platforms are prepared using copper. A new, simple, cost‐efficient and fast high pressure method is used for platform fabrication, through the decomposition of copper hydride. The platform enhancement factors are verified using the malachite green isothiocyanate as a standard. The platforms exhibit extremely high SERS enhancement factors depending on pressure used for their preparation. The calculated enhancement factors have been found in the range between 1.5 × 106 and 4.6 × 107. The SERS spectra reproducibility is established both across a single platform and among different platforms. The average spectral correlation coefficient (Γ) has been calculated to be 0.82. Fully characterized SERS platforms have then been used for detecting Staphylococcus aureus bacteria. These novel platforms have great potential to become excellent tools for biological or medical diagnostics as an alternative to more common silver or gold SERS platforms. Copyright © 2015 John Wiley & Sons, Ltd. The new high pressure technique is used for copper platform fabrication; the applied pressure generates decomposition of the copper hydride. The platform gives excellent enhancement factor (4.6 × 107), very good reproducibility (Γ = 0.82), and stability in time. The possibility to use the copper platform to early‐detection in biology or medicine on an example of Staphylococcus aureus bacteria is presented.
ISSN:0377-0486
1097-4555
DOI:10.1002/jrs.4674