SQUID-based systems for co-registration of ultra-low field nuclear magnetic resonance images and magnetoencephalography

► Co-registration of magnetoencephalography and ultra-low field MRI. ► Description of the design of a hybrid system. ► Optimization of pick-up coils for ultra-low field MRI. ► Suppression of switching transients by a 2nd feedback. ► Development of a clinically relevant multi-channel MEG/ULF MRI syst...

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Bibliographic Details
Published in:Physica. C, Superconductivity Superconductivity, 2012-11, Vol.482, p.19-26
Main Authors: Matlashov, A.N., Burmistrov, E., Magnelind, P.E., Schultz, L., Urbaitis, A.V., Volegov, P.L., Yoder, J., Espy, M.A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Coiling
Devices
Investigative techniques, diagnostic techniques (general aspects)
Low-field MRI
Magnetic fields
Magnetic resonance imaging
Magnetoencephalography
Medical sciences
MEG
Microtesla
MRI
Radiodiagnosis. Nmr imagery. Nmr spectrometry
SQUID
SQUIDs
Superconducting quantum interference devices
ULF
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Summary:► Co-registration of magnetoencephalography and ultra-low field MRI. ► Description of the design of a hybrid system. ► Optimization of pick-up coils for ultra-low field MRI. ► Suppression of switching transients by a 2nd feedback. ► Development of a clinically relevant multi-channel MEG/ULF MRI system. The ability to perform magnetic resonance imaging (MRI) in ultra-low magnetic fields (ULF) of ∼100μT, using superconducting quantum interference device (SQUID) detection, has enabled a new class of magnetoencephalography (MEG) instrumentation capable of recording both anatomical (via the ULF MRI) and functional (biomagnetic) information about the brain. The combined ULF MRI/MEG instrument allows both structural and functional information to be co-registered to a single coordinate system and acquired in a single device. In this paper we discuss the considerations and challenges required to develop a combined ULF MRI/MEG device, including pulse sequence development, magnetic field generation, SQUID operation in an environment of pulsed pre-polarization, and optimization of pick-up coil geometries for MRI in different noise environments. We also discuss the design of a “hybrid” ULF MRI/MEG system under development in our laboratory that uses SQUID pick-up coils separately optimized for MEG and ULF MRI.
ISSN:0921-4534
1873-2143
DOI:10.1016/j.physc.2012.04.028