Aggregation-Resistant Superparamagnetic Noncovalent Hybrid Multilayer Hollow Microcapsules in High Ionic Strength Media

In order to avoid the aggregation and/or fusion of the polyelectrolyte multilayer hollow microcapsules self-assembled via the noncovalent bonds, superparamagnetic polyelectrolyte hybrid hollow microcapsules surface-modified with polyethylene glycol (PEG) brushes were designed and fabricated. After t...

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Bibliographic Details
Published in:Industrial & engineering chemistry research 2012-10, Vol.51 (43), p.13875-13881
Main Authors: Liu, Peng, Li, Xiaorui, Mu, Bin, Du, Pengcheng, Zhao, Xubo, Zhong, Zhuliang
Format: Article
Language:English
Subjects:
Agglomeration
Aldehydes
Applied sciences
Chemical engineering
Chitosan
Exact sciences and technology
Media
Microspheres
Multilayers
Polyelectrolytes
Self assembly
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Summary:In order to avoid the aggregation and/or fusion of the polyelectrolyte multilayer hollow microcapsules self-assembled via the noncovalent bonds, superparamagnetic polyelectrolyte hybrid hollow microcapsules surface-modified with polyethylene glycol (PEG) brushes were designed and fabricated. After the layer-by-layer (LbL) self-assembly of chitosan (CS) and citric acid-modified magnetic nanoparticles (Fe3O4–CA) as the polycation and the hybrid anion on the polystyrene sulfonate microsphere (PSS) templates, respectively, the aldehyde group terminated polyethylene glycol-4000 (APEG) was grafted onto the surface of the superparamagnetic polyelectrolyte hybrid multilayer coated template microspheres via the nucleophilic addition between the aldehyde groups of APEG and the amino groups of CS. Then, the modified superparamagnetic polyelectrolyte hybrid hollow microcapsules were obtained after the templates were removed by dialysis. It was found that the surface PEGylation could prevent aggregation among the hollow microcapsules in the media with high salt concentration by dynamic light scattering (DLS), besides the increase in biocompatibility. The technique developed is expected to realize the application of the polyelectrolyte multilayer hollow microcapsules in real physiological environments.
ISSN:0888-5885
1520-5045
DOI:10.1021/ie301926m