Menstruation pulls the trigger for inflammation and pain in endometriosis

Highlights • Retrograde menstruation and endometriotic lesions release proinflammatory and pro-nociceptive mediators. • Retrograde menstruation is the trigger for inflammation and pain in endometriosis. • Targeting peripheral mechanisms in endometriosis-associated inflammatory pain may lead to impro...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2015-05, Vol.36 (5), p.270-276
Main Authors: Laux-Biehlmann, Alexis, d’Hooghe, Thomas, Zollner, Thomas M
Format: Article
Language:English
Subjects:
Advanced Basic Science
endometriosis
Endometriosis - physiopathology
Female
Humans
Inflammation - physiopathology
inflammatory pain
Menstrual Cycle - immunology
Menstrual Cycle - metabolism
Menstrual Cycle - physiology
neurogenic inflammation
Nociceptive Pain - physiopathology
retrograde menstruation
sensory nerves
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Summary:Highlights • Retrograde menstruation and endometriotic lesions release proinflammatory and pro-nociceptive mediators. • Retrograde menstruation is the trigger for inflammation and pain in endometriosis. • Targeting peripheral mechanisms in endometriosis-associated inflammatory pain may lead to improved treatment. • Mechanisms causing inflammatory pain in endometriosis are relevant for other inflammatory disorders.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2015.03.004