Featuring the nucleosome surface as a therapeutic target

Highlights • Chromatin dynamics depend on competition by NBPs and the histone H4 tail to bind to the nucleosome's acidic patch. • eNBMs and distinct NBPs lead to specific chromatin and cellular states. • The nucleosome surface is a therapeutic target. • Peptide-like molecules are the most promi...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2015-05, Vol.36 (5), p.263-269
Main Authors: Silva, Isabel Torres Gomes da, Oliveira, Paulo Sergio Lopes de, Santos, Guilherme Martins
Format: Article
Language:English
Subjects:
acidic patch
Advanced Basic Science
Amino Acid Sequence
Animals
Base Sequence
binding protein
chromatin
Humans
Molecular Docking Simulation
Molecular Sequence Data
nucleosome
Nucleosomes - chemistry
Nucleosomes - drug effects
Nucleosomes - metabolism
Peptides - pharmacology
Peptidomimetics - pharmacology
Protein Binding
structure
therapeutic target
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Summary:Highlights • Chromatin dynamics depend on competition by NBPs and the histone H4 tail to bind to the nucleosome's acidic patch. • eNBMs and distinct NBPs lead to specific chromatin and cellular states. • The nucleosome surface is a therapeutic target. • Peptide-like molecules are the most promising eNBMs.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2015.02.010