Association of Basal and Calcium-stimulated Calcitonin Levels with Pathological Findings After Total Thyroidectomy

Medullary thyroid carcinoma (MTC) originates from thyroid C-cells and is a calcitonin-secreting tumor. Calcitonin is also elevated in C-cell hyperplasia (CCH). The objective of the study was to determine the optimal basal (bCT) and peak stimulated calcitonin (psCT) cut-off value for differentiating...

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Bibliographic Details
Published in:Anticancer research 2015-07, Vol.35 (7), p.4251-4258
Main Authors: Papadakis, Georgios, Keramidas, Ioannis, Triantafillou, Eleni, Kanouta, Fotini, Pappa, Theodora, Kaltzidou, Victoria, Tertipi, Athanasia, Iordanidou, Lydia, Trivizaki, Erasmia, Vecchini, Gino, Villiotou, Vassiliki, Pappas, Anastasios
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Calcitonin - metabolism
Calcium - metabolism
Carcinoma, Neuroendocrine
Female
Humans
Male
Middle Aged
Thyroid Gland - metabolism
Thyroid Gland - surgery
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - surgery
Thyroidectomy - methods
Young Adult
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Summary:Medullary thyroid carcinoma (MTC) originates from thyroid C-cells and is a calcitonin-secreting tumor. Calcitonin is also elevated in C-cell hyperplasia (CCH). The objective of the study was to determine the optimal basal (bCT) and peak stimulated calcitonin (psCT) cut-off value for differentiating MTC from CCH, and to examine the histological findings of thyroidectomy in patients with maximum psCT >100 pg/ml. Fifty-five patients had a maximum calcium-psCT >100 pg/ml and underwent total thyroidectomy. A total of 20 patients were diagnosed with MTC and the remaining 35 with CCH. A bCT level >17.4 pg/ml and psCT level >452 pg/ml demonstrated the best sensitivity and positive predictive value for differenting MTC from CCH. The overlap of calcitonin levels between MTC and CCH reduces the accuracy of the calcium stimulation test. Remarkably, an appreciable number of patients with psCT levels >100 pg/ml harbor differentiated thyroid carcinoma of follicular origin.
ISSN:1791-7530