Use of modified Magee equations and histologic criteria to predict the Oncotype DX recurrence score

Oncotype DX (Genomic Health, Redwood City, CA, USA, current list price $4,350.00) is a multigene quantitative reverse transcription-polymerase chain reaction-based assay that estimates the risk of distant recurrence and predicts chemotherapy benefit for patients with estrogen receptor (ER)-positive...

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Bibliographic Details
Published in:Modern pathology 2015-07, Vol.28 (7), p.921-931
Main Authors: Turner, Bradley M, Skinner, Kristin A, Tang, Ping, Jackson, Mary C, Soukiazian, Nyrie, Shayne, Michelle, Huston, Alissa, Ling, Marilyn, Hicks, David G
Format: Article
Language:English
Subjects:
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692/53/2423
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Female
Gene Expression Profiling
Humans
Laboratory Medicine
Medicine
Medicine & Public Health
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
original-article
Pathology
Prognosis
Risk
Risk Assessment
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Summary:Oncotype DX (Genomic Health, Redwood City, CA, USA, current list price $4,350.00) is a multigene quantitative reverse transcription-polymerase chain reaction-based assay that estimates the risk of distant recurrence and predicts chemotherapy benefit for patients with estrogen receptor (ER)-positive breast cancers. Studies have suggested that standard histologic variables can provide similar information. Klein and Dabbs et al have shown that Oncotype DX recurrence scores can be estimated by incorporating standard histologic variables into equations (Magee equations). Using a simple modification of the Magee equation, we predict the Oncotype DX recurrence score in an independent set of 283 cases. The Pearson correlation coefficient (r) for the Oncotype DX and average modified Magee recurrence scores was 0.6644 ( n =283; P 30 ( n =8) or an average modified Magee recurrence score
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2015.50