Intractability in Epilepsy: Role of EEG Desynchronization in Early Identification

In view of several studies that have reported decreased REMS in IE, and its restoration and even enhancement by alternative therapies like ketogenic diet, vagal nerve stimulation, temporal lobe surgery, REMS has been proposed as a biomarker of IE.9 This has led to the suggestion of superiority of po...

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Bibliographic Details
Published in:Clinical EEG and neuroscience 2015-07, Vol.46 (3), p.266-267
Main Author: Jaseja, Harinder
Format: Article
Language:English
Subjects:
Convulsions & seizures
Early Diagnosis
Electroencephalography - methods
Electroencephalography Phase Synchronization
Epilepsy
Epilepsy - diagnosis
Epilepsy - physiopathology
Eye movements
Humans
Sleep
Sleep Wake Disorders - diagnosis
Sleep Wake Disorders - physiopathology
Sleep, REM
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Summary:In view of several studies that have reported decreased REMS in IE, and its restoration and even enhancement by alternative therapies like ketogenic diet, vagal nerve stimulation, temporal lobe surgery, REMS has been proposed as a biomarker of IE.9 This has led to the suggestion of superiority of polysomnography over EEG, in assessment of epilepsy. 10 The protective antiepileptic action of REMS possibly follows a linear relation to the duration of REMS.11 Based on the strong antiepileptic action of REMS, a novel therapy has also been proposed for IE.12 Induction of desynchronization, usually at high frequencies in the range of 100 to 180 Hz, has been proposed as an important objective of deep brain stimulation (DBS).13 In the author's experience, in patients with IE who underwent bilateral anterior thalamic nucleus DBS, at routine high frequencies of stimulation, desynchronization was significantly more difficult to attain in patients who responded poorly.
ISSN:1550-0594
2169-5202
DOI:10.1177/1550059414528311