Lateralisation abnormalities in obsessive–compulsive disorder: a line bisection study

Asymmetry in brain structure and function is implicated in the pathogenesis of psychiatric disorders. Although right hemisphere abnormality has been documented in obsessive-compulsive disorder (OCD), cerebral asymmetry is rarely examined. Therefore, in this study, we examined anomalous cerebral asym...

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Bibliographic Details
Published in:Acta neuropsychiatrica 2015-08, Vol.27 (4), p.242-247
Main Authors: Rao, Naren Prahlada, Arasappa, Rashmi, Reddy, Nalini Narayana, Venkatasubramanian, Ganesan, Reddy Y.C., Janardhan
Format: Article
Language:English
Subjects:
Adult
Analysis of covariance
Anisotropy
Asymmetry
Blindness
Brain - abnormalities
Brain - physiopathology
Case-Control Studies
Cognition & reasoning
Cross-Sectional Studies
Female
Functional Laterality - classification
Functional Laterality - physiology
Humans
Male
Mental disorders
Neuroimaging - methods
Neurological disorders
Neuropsychological Tests
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - physiopathology
Pathogenesis
Psychiatrists
Questionnaires
Schizophrenia
Short Communications
Tourette syndrome
Visual impairment
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Summary:Asymmetry in brain structure and function is implicated in the pathogenesis of psychiatric disorders. Although right hemisphere abnormality has been documented in obsessive-compulsive disorder (OCD), cerebral asymmetry is rarely examined. Therefore, in this study, we examined anomalous cerebral asymmetry in OCD patients using the line bisection task. A total of 30 patients with OCD and 30 matched healthy controls were examined using a reliable and valid two-hand line bisection (LBS) task. The comparative profiles of LBS scores were analysed using analysis of covariance. Patients with OCD bisected significantly less number of lines to the left and had significant rightward deviation than controls, indicating right hemisphere dysfunction. The correlations observed in this study suggest that those with impaired laterality had more severe illness at baseline. The findings of this study indicate abnormal cerebral lateralisation and right hemisphere dysfunction in OCD patients.
ISSN:0924-2708
1601-5215
DOI:10.1017/neu.2015.23