Targeting dengue virus NS4B protein for drug discovery

•DENV NS4B is a small integral membrane protein with high hydrophobicity.•DENV NS4B engages in a complex network of protein–protein interactions.•DENV NS4B involves in evasion of host immune responses.•DENV NS4B has emerged as a valid antiviral target for drug discovery. The flavivirus nonstructural...

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Bibliographic Details
Published in:Antiviral research 2015-06, Vol.118, p.39-45
Main Authors: Xie, Xuping, Zou, Jing, Wang, Qing-Yin, Shi, Pei-Yong
Format: Article
Language:English
Subjects:
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Antivirals
Dengue
Dengue Virus - drug effects
Dengue Virus - physiology
Drug Discovery - methods
Drug Discovery - trends
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Flavivirus
Humans
Nonstructural protein 4B
NS4B
Viral Nonstructural Proteins - antagonists & inhibitors
Viral Nonstructural Proteins - chemistry
Viral Nonstructural Proteins - metabolism
Virus Replication - drug effects
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Summary:•DENV NS4B is a small integral membrane protein with high hydrophobicity.•DENV NS4B engages in a complex network of protein–protein interactions.•DENV NS4B involves in evasion of host immune responses.•DENV NS4B has emerged as a valid antiviral target for drug discovery. The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2015.03.007