Lysophospholipids from the Guangxi Sponge Spirastrella purpurea

Four known (1–4) and two new (5 and 6) lysophospholipids were isolated from the sponge Spirastrella purpurea from Weizhou Island, Guangxi Autonomous Region, China. The structures of the new compounds (5 and 6) were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR (¹H and ¹³C...

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Bibliographic Details
Published in:Lipids 2015-07, Vol.50 (7), p.697-703
Main Authors: Lin, Kun, Yang, Peng, Yang, Hui, Liu, Ai-Hong, Yao, Li-Gong, Guo, Yue-Wei, Mao, Shui-Chun
Format: Article
Language:English
Subjects:
Animals
Antifungal activity
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
antifungal properties
Aspergillus fumigatus
Aspergillus fumigatus - drug effects
Biomedical and Life Sciences
Candida glabrata
Candida glabrata - drug effects
carbon
Cell Line
Cell Proliferation - drug effects
Communication
Cryptococcus neoformans
Cryptococcus neoformans - drug effects
fungi
Guangxi
HPLC
Humans
hydrogen
Life Sciences
Lipidology
Lysophospholipids
Lysophospholipids - chemistry
Lysophospholipids - isolation & purification
Lysophospholipids - pharmacology
Magnetic Resonance Spectroscopy
Marine natural products
Mass spectrometry
Medical Biochemistry
Medicinal Chemistry
Microbial Genetics and Genomics
Neurochemistry
Neuroprotective activity
neuroprotective effect
NMR
nuclear magnetic resonance spectroscopy
Nutrition
Porifera - chemistry
spectral analysis
Spirastrella purpurea
Sponge
stable isotopes
Trichophyton - drug effects
Trichophyton rubrum
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Summary:Four known (1–4) and two new (5 and 6) lysophospholipids were isolated from the sponge Spirastrella purpurea from Weizhou Island, Guangxi Autonomous Region, China. The structures of the new compounds (5 and 6) were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR (¹H and ¹³C NMR, ¹H–¹H COSY, HSQC, and HMBC) as well as mass spectrometry and optical rotation experiments. The known compounds (1–4) were identified by comparison of their spectroscopic data and specific optical rotation with those reported in the literature. The isolated compounds displayed various moderate in vitro antifungal activities against four fungi (Cryptococcus neoformans, Candida glabrata, Trichophyton rubrum, and Aspergillus fumigatus), whereas they displayed no neuroprotective activity against Aβ₂₅₋₃₅-induced SH-SY5Y cell damage.
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-015-4028-6