Role of dietary pro‐oxidants in the maintenance of health and resilience to oxidative stress

The average length of human life is increasing, but so does the incidence of age‐ and lifestyle‐related diseases. Improving diet and lifestyle is a key strategy for lifelong health and underlying mechanisms may well include increasing resilience pathways. The purpose of this review is to highlight a...

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Bibliographic Details
Published in:Molecular nutrition & food research 2015-07, Vol.59 (7), p.1229-1248
Main Authors: de Roos, Baukje, Duthie, Garry G
Format: Article
Language:English
Subjects:
Antioxidants
Antioxidants - pharmacology
Diet
Dietary fatty acids
Disease Resistance
enzymes
Enzymes - metabolism
fatty acids
heat shock proteins
Humans
in vivo studies
lifestyle
NF-E2-Related Factor 2 - genetics
Oxidative stress
Oxidative Stress - drug effects
phytopharmaceuticals
Polyphenols
reactive oxygen species
Reactive Oxygen Species - metabolism
Resilience
transcription factors
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Summary:The average length of human life is increasing, but so does the incidence of age‐ and lifestyle‐related diseases. Improving diet and lifestyle is a key strategy for lifelong health and underlying mechanisms may well include increasing resilience pathways. The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro‐oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf‐2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. An increasing number of in vivo studies have now shown that dietary pro‐oxidant compounds can increase the production of such resilience products. In most studies, dietary pro‐oxidants normalized levels of antioxidant enzymes that were decreased by a range of different challenges, rather than raising levels of resilience products per se. Also, it is important to consider that the antioxidant response can be different for different organs. For future studies, however, the measurement of resilience markers may significantly improve our ability to prove the efficacy by which dietary bioactives with pro‐oxidant capacities improve lifelong health.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201400568