Contribution of transplantations to the understanding of the role of the PLP gene

We present an overview of the results obtained in a cross-transplantation system using respectively controls, jimpy (jp), and shiverer mutant mice as donors and recipients. Homochronic transplantations (O days into O days) demonstrated that jp environment is non-toxic for non-jp cells and that, cont...

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Bibliographic Details
Published in:Neurochemical research 1994-08, Vol.19 (8), p.1083-1090
Main Authors: LACHAPELLE, F, GUMPEL, M, BAUMANN, N
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Tissue Transplantation - physiology
Fetal Tissue Transplantation - physiology
Fundamental and applied biological sciences. Psychology
Isolated neuron and nerve. Neuroglia
Mice
Mice, Jimpy
Mice, Neurologic Mutants
Myelin Proteins - genetics
Myelin Proteolipid Protein
Oligodendroglia - cytology
Oligodendroglia - physiology
Phenotype
Tissue Donors
Vertebrates: nervous system and sense organs
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Summary:We present an overview of the results obtained in a cross-transplantation system using respectively controls, jimpy (jp), and shiverer mutant mice as donors and recipients. Homochronic transplantations (O days into O days) demonstrated that jp environment is non-toxic for non-jp cells and that, contrary to in vitro, jp oligodendrocytes phenotype cannot be modified by environmental factors at this age. Transplantations of embryonic fragments into the newborn brain demonstrated that in contrast to oligodendrocyte precursors contained in fragments of newborn tissue, jimpy embryonic stem cells are sensitive to environmental factors able to modulate the proportion of surviving oligodendrocytes. In addition, these series evidenced a disjunction between the surviving and the myelinating capacity of jp cells demonstrating a pleiotropic effect of the jp mutation on oligodendrocyte biology. Results are discussed with regards to the recent molecular biological finding on the role of the DM20/PLP gene.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00968720