Anti-plasmodial activity of bradykinin and analogs

[Display omitted] To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity agains...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2015-08, Vol.25 (16), p.3311-3313
Main Authors: Silva, Adriana F., Alves, Flávio L., Pedron, Cibele N., Torres, Marcelo D.T., Silva, Leandro S., Pinheiro, Ana A.S., Miranda, Antonio, Oliveira, Vani X.
Format: Article
Language:English
Subjects:
Animals
Anti-plasmodial
Antimalarials - chemical synthesis
Antimalarials - chemistry
Antimalarials - pharmacology
Bradykinin
Bradykinin - chemistry
Bradykinin - genetics
Bradykinin - pharmacology
Humans
Malaria
Peptides
Peptides - chemical synthesis
Peptides - chemistry
Peptides - genetics
Peptides - pharmacology
Plasmodium
Plasmodium falciparum - drug effects
Plasmodium gallinaceum - drug effects
Sporozoites - drug effects
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Summary:[Display omitted] To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2015.05.071