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Anti-plasmodial activity of bradykinin and analogs
[Display omitted] To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity agains...
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| Published in: | Bioorganic & medicinal chemistry letters 2015-08, Vol.25 (16), p.3311-3313 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c356t-acfc2aa3f28c0f7d7b42041103bb919884d9c5b6f65b75a1d00c36a96042dc5b3 |
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| cites | cdi_FETCH-LOGICAL-c356t-acfc2aa3f28c0f7d7b42041103bb919884d9c5b6f65b75a1d00c36a96042dc5b3 |
| container_end_page | 3313 |
| container_issue | 16 |
| container_start_page | 3311 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 25 |
| creator | Silva, Adriana F. Alves, Flávio L. Pedron, Cibele N. Torres, Marcelo D.T. Silva, Leandro S. Pinheiro, Ana A.S. Miranda, Antonio Oliveira, Vani X. |
| description | [Display omitted]
To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum. |
| doi_str_mv | 10.1016/j.bmcl.2015.05.071 |
| format | article |
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To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2015.05.071</identifier><identifier>PMID: 26077496</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Anti-plasmodial ; Antimalarials - chemical synthesis ; Antimalarials - chemistry ; Antimalarials - pharmacology ; Bradykinin ; Bradykinin - chemistry ; Bradykinin - genetics ; Bradykinin - pharmacology ; Humans ; Malaria ; Peptides ; Peptides - chemical synthesis ; Peptides - chemistry ; Peptides - genetics ; Peptides - pharmacology ; Plasmodium ; Plasmodium falciparum - drug effects ; Plasmodium gallinaceum - drug effects ; Sporozoites - drug effects</subject><ispartof>Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3311-3313</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-acfc2aa3f28c0f7d7b42041103bb919884d9c5b6f65b75a1d00c36a96042dc5b3</citedby><cites>FETCH-LOGICAL-c356t-acfc2aa3f28c0f7d7b42041103bb919884d9c5b6f65b75a1d00c36a96042dc5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26077496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Adriana F.</creatorcontrib><creatorcontrib>Alves, Flávio L.</creatorcontrib><creatorcontrib>Pedron, Cibele N.</creatorcontrib><creatorcontrib>Torres, Marcelo D.T.</creatorcontrib><creatorcontrib>Silva, Leandro S.</creatorcontrib><creatorcontrib>Pinheiro, Ana A.S.</creatorcontrib><creatorcontrib>Miranda, Antonio</creatorcontrib><creatorcontrib>Oliveira, Vani X.</creatorcontrib><title>Anti-plasmodial activity of bradykinin and analogs</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. 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To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26077496</pmid><doi>10.1016/j.bmcl.2015.05.071</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3311-3313 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Anti-plasmodial Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Bradykinin Bradykinin - chemistry Bradykinin - genetics Bradykinin - pharmacology Humans Malaria Peptides Peptides - chemical synthesis Peptides - chemistry Peptides - genetics Peptides - pharmacology Plasmodium Plasmodium falciparum - drug effects Plasmodium gallinaceum - drug effects Sporozoites - drug effects |
| title | Anti-plasmodial activity of bradykinin and analogs |
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