Combination of retrograde superselective intra-arterial chemotherapy and Seldinger method in locally advanced oral cancer

• Published in: Journal of cancer research and therapeutics 2015-04, Vol.11 (2), p.475-478
• Main Authors: Uehara, Masataka, Ohya, Ryouichi, Kodama, Masaaki, Shiraishi, Takeshi, Asahina, Izumi, Tominaga, Kazuhiro
• Format: Article
• Language: English
• Subjects: Aged; Analysis; Antineoplastic Agents - administration & dosage; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - radiotherapy; Catheters; Chemotherapy; Chemotherapy, Adjuvant - methods; Cisplatin - administration & dosage; Drug therapy; Female; Health aspects; Humans; Infusions, Intra-Arterial - methods; Lymph Nodes - drug effects; Lymph Nodes - radiation effects; Lymphatic Metastasis - radiotherapy; Lymphatic system; Methods; Middle Aged; Mouth cancer; Mouth Neoplasms - drug therapy; Mouth Neoplasms - radiotherapy; Veins & arteries
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/0973-1482.140833

The nonsurgical strategies for locally advanced oral cancer are desirable. Superselective intra-arterial infusion with radiotherapy was utilized for this purpose, and there are two types of superselective intra-arterial infusion methods: The Seldinger method and the retrograde superselective intra-arterial chemotherapy (HFT method). In one case, the HFT method was applied to locally advanced tongue cancer, and the Seldinger method was used for additional administration of cisplatin (CDDP) to compensate for a lack of drug flow in the HFT method. In another case, the HFT method was applied to locally advanced lower gingival cancer. The Seldinger method was applied to metastatic lymph nodes. In both cases, additional administration of CDDP using the Seldinger method resulted in a complete response. The combination of the HFT and Seldinger methods was useful to eradicate locally advanced oral cancer because each method compensated for the defects of the other.