Golgi post-translational modifications and associated diseases

For non specialists, Golgi is a very well known subcellular compartment involved in secretion and correct targeting of soluble and transmembrane proteins. Nevertheless, Golgi is also specifically involved in many different and diverse post-translational modifications. Through its diverse functions,...

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Bibliographic Details
Published in:Journal of inherited metabolic disease 2015-07, Vol.38 (4), p.741-751
Main Authors: Potelle, Sven, Klein, André, Foulquier, François
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Golgi Apparatus - genetics
Golgi Apparatus - metabolism
Human Genetics
Humans
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic Diseases - genetics
Metabolic Diseases - metabolism
Pediatrics
Protein Processing, Post-Translational - genetics
Ssiem 2014
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Summary:For non specialists, Golgi is a very well known subcellular compartment involved in secretion and correct targeting of soluble and transmembrane proteins. Nevertheless, Golgi is also specifically involved in many different and diverse post-translational modifications. Through its diverse functions, Golgi is not only able to modify secreted and transmembrane proteins but also cytoplasmic proteins. The Golgi apparatus research field is so broad that an exhaustive review of this organelle is not doable here. The goal of this review is to cover the main post-translational modifications occurring at the Golgi level and present the identified associated diseases.
ISSN:0141-8955
1573-2665
DOI:10.1007/s10545-015-9851-7