Aberrant GSTP1 promoter methylation predicts short‐term prognosis in acute‐on‐chronic hepatitis B liver failure

Summary Background Glutathione‐S‐transferase P1 (GSTP1) methylation has been demonstrated to be associated with oxidative stress induced liver damage in acute‐on‐chronic hepatitis B liver failure (ACHBLF). Aim To evaluate the methylation level of GSTP1 promoter in acute‐on‐chronic hepatitis B liver...

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Published in:Alimentary pharmacology & therapeutics 2015-08, Vol.42 (3), p.319-329
Main Authors: Gao, S., Sun, F.‐K., Fan, Y.‐C., Shi, C.‐H., Zhang, Z.‐H., Wang, L.‐Y., Wang, K.
Format: Article
Language:English
Subjects:
Adult
Bilirubin - metabolism
DNA Methylation
Female
Glutathione Transferase - genetics
Hepatitis B, Chronic - complications
Humans
Leukocytes, Mononuclear - metabolism
Liver Failure - virology
Male
Middle Aged
Oxidative Stress
Prognosis
Promoter Regions, Genetic
Retrospective Studies
ROC Curve
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Summary:Summary Background Glutathione‐S‐transferase P1 (GSTP1) methylation has been demonstrated to be associated with oxidative stress induced liver damage in acute‐on‐chronic hepatitis B liver failure (ACHBLF). Aim To evaluate the methylation level of GSTP1 promoter in acute‐on‐chronic hepatitis B liver failure and determine its predictive value for prognosis. Methods One hundred and five patients with acute‐on‐chronic hepatitis B liver failure, 86 with chronic hepatitis B (CHB) and 30 healthy controls (HC) were retrospectively enrolled. GSTP1 methylation level in peripheral mononuclear cells (PBMC) was detected by MethyLight. Clinical and laboratory parameters were obtained. Results GSTP1 methylation levels were significantly higher in patients with acute‐on‐chronic hepatitis B liver failure (median 16.84%, interquartile range 1.83–59.05%) than those with CHB (median 1.25%, interquartile range 0.48–2.47%; P 
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.13271