Tissue engineering strategies to study cartilage development, degeneration and regeneration

Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chon...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2015-04, Vol.84, p.107-122
Main Authors: Bhattacharjee, Maumita, Coburn, Jeannine, Centola, Matteo, Murab, Sumit, Barbero, Andrea, Kaplan, David L., Martin, Ivan, Ghosh, Sourabh
Format: Article
Language:English
Subjects:
Cartilage - pathology
Cartilage - physiology
Cartilage tissue
Chondrogenesis - physiology
Developmental biology
Drug targets
Humans
In vitro models
In Vitro Techniques - methods
Regeneration - physiology
Scaffolds
Signals
Stem Cell Transplantation - methods
Tissue Engineering - methods
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Summary:Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation. We then review how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration. The generated knowledge is expected to inform new cartilage regeneration strategies, beyond a classical tissue engineering paradigm. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2014.08.010