A novel aminotriazole-based NHC complex for the design of gold( i ) anti-cancer agents: synthesis and biological evaluation

A novel gold( i ) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase a...

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Bibliographic Details
Published in:MedChemComm 2015-06, Vol.6 (6), p.1186-1189
Main Authors: Serebryanskaya, T. V., Zolotarev, A. A., Ott, I.
Format: Article
Language:English
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Summary:A novel gold( i ) complex based on an aminotriazole N-heterocylic carbene ligand represents a promising scaffold for the design of anticancer bioorganometallics. The complex triggered cytotoxic effects in HT-29 and MDA-MB-231 cancer cells, inhibited the activity of the enzyme thioredoxin reductase and showed an effective and fast cellular accumulation.
ISSN:2040-2503
2040-2511
DOI:10.1039/C5MD00185D