Progress towards understanding the genetics of posttraumatic stress disorder

Highlights • We have comprehensively reviewed the literature on the genetics of PTSD. • A number of genes have been shown to be associated with PTSD. • GWAS studies are limited because of the large samples required. • Epigenetics has shown to play a vital role in PTSD susceptibility. • Much of the g...

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Bibliographic Details
Published in:Journal of anxiety disorders 2014-12, Vol.28 (8), p.873-883
Main Authors: Voisey, Joanne, Young, Ross McD, Lawford, Bruce R, Morris, Charles P
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anxiety
Anxiety disorders. Neuroses
Biological and medical sciences
Comprehension
Epigenesis, Genetic
Epigenetics
Gene-Environment Interaction
Genetics
Genome-Wide Association Study
Humans
Medical sciences
Post-traumatic stress disorder
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
PTSD
Signal Transduction - genetics
Stress Disorders, Post-Traumatic - genetics
Stress Disorders, Post-Traumatic - therapy
Trauma
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Summary:Highlights • We have comprehensively reviewed the literature on the genetics of PTSD. • A number of genes have been shown to be associated with PTSD. • GWAS studies are limited because of the large samples required. • Epigenetics has shown to play a vital role in PTSD susceptibility. • Much of the genetic risk still remains unknown.
ISSN:0887-6185
1873-7897
DOI:10.1016/j.janxdis.2014.09.014