Hikiamides A–C, Cyclic Pentadepsipeptides from Fusarium sp. TAMA 456

Three new cyclic pentadepsipeptides, hikiamides A–C (1–3), were isolated from the culture extract of Fusarium sp. TAMA 456. The structures were determined by spectroscopic analysis using NMR and MS, and the absolute configurations were established by using Marfey’s method and chiral HPLC analysis. H...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2015-04, Vol.78 (4), p.797-802
Main Authors: Fukuda, Takao, Sudoh, Yuri, Tsuchiya, Yuki, Okuda, Toru, Matsuura, Nobuyasu, Motojima, Atsuko, Oikawa, Tsutomu, Igarashi, Yasuhiro
Format: Article
Language:English
Subjects:
Adipocytes - drug effects
Animals
Base Sequence
Chromatography, High Pressure Liquid
Depsipeptides - chemistry
Depsipeptides - isolation & purification
Fusarium
Fusarium - chemistry
Luciferases - metabolism
Mice
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Polymerase Chain Reaction
PPAR gamma - metabolism
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Summary:Three new cyclic pentadepsipeptides, hikiamides A–C (1–3), were isolated from the culture extract of Fusarium sp. TAMA 456. The structures were determined by spectroscopic analysis using NMR and MS, and the absolute configurations were established by using Marfey’s method and chiral HPLC analysis. Hikiamides induced the differentiation of murine ST-13 preadipocytes into mature adipocytes at 2 μM and adiponectin mRNA expression (5- to 13-fold higher than control). They also induced PPAR-γ-dependent gene expression at a concentration from 0.63 to 10 μM in a gene reporter assay.
ISSN:0163-3864
1520-6025
DOI:10.1021/np501047a