The expanding universe of disorders of the basal ganglia

Summary The basal ganglia were originally thought to be associated purely with motor control. However, dysfunction and pathology of different regions and circuits are now known to give rise to many clinical manifestations beyond the association of basal ganglia dysfunction with movement disorders. M...

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Bibliographic Details
Published in:The Lancet (British edition) 2014-08, Vol.384 (9942), p.523-531
Main Authors: Obeso, Jose A, Prof, Rodriguez-Oroz, Maria C, MD, Stamelou, Maria, MD, Bhatia, Kailash P, MD, Burn, David J, Prof
Format: Article
Language:English
Subjects:
Basal Ganglia - physiopathology
Basal Ganglia Diseases - genetics
Basal Ganglia Diseases - physiopathology
Biomedical research
Dopamine
Humans
Internal Medicine
Limbic System - physiology
Movement Disorders - genetics
Movement Disorders - physiopathology
Parkinson Disease - physiopathology
Parkinson's disease
Pharmaceuticals
Tourette Syndrome - physiopathology
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Summary:Summary The basal ganglia were originally thought to be associated purely with motor control. However, dysfunction and pathology of different regions and circuits are now known to give rise to many clinical manifestations beyond the association of basal ganglia dysfunction with movement disorders. Moreover, disorders that were thought to be caused by dysfunction of the basal ganglia only, such as Parkinson's disease and Huntington's disease, have diverse abnormalities distributed not only in the brain but also in the peripheral and autonomic nervous systems; this knowledge poses new questions and challenges. We discuss advances and the unanswered questions, and ways in which progress might be made.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(13)62418-6