Metabolic, hormonal characteristics and genetic variants of TCF7L2 associated with development of gestational diabetes mellitus in Mexican women

Background Variation in TCF7L2 gene is associated with type 2 diabetes and with gestational diabetes mellitus in several populations, but there are no data in Mexican women with gestational diabetes mellitus. In this study, we examined metabolic and hormonal measurements as well as TCF7L2 genetic va...

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Bibliographic Details
Published in:Diabetes/metabolism research and reviews 2014-11, Vol.30 (8), p.701-706
Main Authors: Reyes-López, Ruth, Pérez-Luque, Elva, Malacara, Juan Manuel
Format: Article
Language:English
Subjects:
Adult
Alleles
Birth weight
Body Mass Index
Cholesterol, HDL - analysis
Cross-Sectional Studies
Diabetes
Diabetes, Gestational - blood
Diabetes, Gestational - etiology
Diabetes, Gestational - genetics
Diabetes, Gestational - physiopathology
Female
GDM hormonal characteristics
Generalized linear models
Genetic Association Studies
Genetic Predisposition to Disease
gestational diabetes
Glucagon-Like Peptide 1 - blood
Humans
Insulin
Insulin - blood
Insulin - metabolism
Insulin resistance
Insulin Secretion
Insulin-Secreting Cells - metabolism
Maternal Nutritional Physiological Phenomena
Metabolism
Mexico
Overweight - physiopathology
Polymorphism, Single Nucleotide
Pregnancy
TCF7L2 gene polymorphisms
Transcription Factor 7-Like 2 Protein - genetics
Young Adult
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Summary:Background Variation in TCF7L2 gene is associated with type 2 diabetes and with gestational diabetes mellitus in several populations, but there are no data in Mexican women with gestational diabetes mellitus. In this study, we examined metabolic and hormonal measurements as well as TCF7L2 genetic variants. Methods We selected 108 pregnant women with normal glucose tolerance and 90 with gestational diabetes mellitus according to 2010 American Diabetes Association criteria matched for gestational week. We collected data on blood pressure, body mass index (BMI) and concentrations of blood glucose, HbA1c, lipids profile, insulin and glucagon‐like peptide‐1 (GLP‐1). The genotyping of rs7903146 and rs12255372 polymorphisms were made with polymerase chain reaction–restriction fragment length polymorphism. Results Actual and pre‐gestational BMI, fasting glucose and HbA1c were higher (p 
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.2538