ELN and FBN2 Gene Variants as Risk Factors for Two Sports-related Musculoskeletal Injuries

Abstract The proteins ELN and FBN2 are important in extracellular matrix function. The ELN rs2071307 and FBN2 rs331079 gene variants have been associated with soft tissue pathologies. We aimed to determine whether these variants were predisposing factors for both Achilles tendinopathy (AT) and anter...

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Bibliographic Details
Published in:International journal of sports medicine 2015-04, Vol.36 (4), p.333-337
Main Authors: Khoury, L. El, Posthumus, M., Collins, M., van der Merwe, W., Handley, C., Cook, J., Raleigh, S. M.
Format: Article
Language:English
Subjects:
Achilles Tendon - injuries
Adult
Anterior Cruciate Ligament Injuries
Case-Control Studies
Elastin - genetics
Female
Fibrillin-2
Fibrillins
Genetics & Molecular Biology
Genotype
Humans
Male
Microfilament Proteins - genetics
Middle Aged
Risk Factors
Rupture - genetics
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Summary:Abstract The proteins ELN and FBN2 are important in extracellular matrix function. The ELN rs2071307 and FBN2 rs331079 gene variants have been associated with soft tissue pathologies. We aimed to determine whether these variants were predisposing factors for both Achilles tendinopathy (AT) and anterior cruciate ligament (ACL) ruptures. For the AT study, 135 cases (TEN group) and 239 asymptomatic controls were recruited. For the ACL rupture study our cohort consisted of 141 cases (ACL group) and 219 controls. Samples were genotyped for both the ELN rs2071307 and FBN2 rs331079 variants using TaqMan assays. Analysis of variance and chi-squared tests were used to determine whether either variant was associated with AT or ACL rupture with significance set at p
ISSN:0172-4622
1439-3964
DOI:10.1055/s-0034-1390492