Common Variants of Apolipoprotein E and Cholesteryl Ester Transport Protein Genes in Male Patients With Coronary Heart Disease and Variable Body Mass Index

Plasma lipids are major risk factors for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) and apolipoprotein (apo) E genes are involved in lipoprotein metabolism, thus affecting plasma lipid and lipoproteins levels. Furthermore, such polymorphisms have been associated with sus...

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Bibliographic Details
Published in:Angiology 2015-02, Vol.66 (2), p.169-173
Main Authors: Kolovou, Genovefa D., Panagiotakos, Demosthenes B., Kolovou, Vana, Vasiliadis, Ioannis, Giannakopoulou, Vasiliki, Diakoumakou, Olga, Katsiki, Niki, Mavrogeni, Sophie
Format: Article
Language:English
Subjects:
Aged
Apolipoprotein E2 - genetics
Apolipoprotein E3 - genetics
Apolipoprotein E4 - genetics
Apolipoproteins E - genetics
Biomarkers - blood
Body Mass Index
Cholesterol Ester Transfer Proteins - genetics
Cholesterol, LDL - blood
Coronary Disease - blood
Coronary Disease - diagnosis
Coronary Disease - genetics
Genetic Predisposition to Disease
Genetic Variation
Greece
Humans
Male
Middle Aged
Phenotype
Risk Factors
Triglycerides - blood
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Summary:Plasma lipids are major risk factors for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) and apolipoprotein (apo) E genes are involved in lipoprotein metabolism, thus affecting plasma lipid and lipoproteins levels. Furthermore, such polymorphisms have been associated with susceptibility to CHD and obesity. We evaluated the influence of the gene polymorphisms of CETP TaqIB (B1, B2) and I405V (V, I) and apo E (∊2,∊3,∊4) on lipid levels, according to body mass index (BMI) in Greek men with CHD. The TaqIB (B1, B2) polymorphism affected plasma low-density lipoprotein cholesterol levels in overweight men with CHD, whereas the I405V (V, I) polymorphism affected triglyceride concentrations in normal weight men. No correlation was found between BMI and apo E polymorphisms. Large prospective studies are required to investigate the relationships of CETP and apo E polymorphisms with lipids, BMI, and CHD susceptibility.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319713517927