The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence

Highlights • DAT1 gene was analyzed in patients with amphetamine dependence (AD), and different personality. • A weak association was found between the rs27072 polymorphism and development of AD. • The borderline associations were not evident in subsequent correction. • High harm avoidance and novel...

Full description

Saved in:
Bibliographic Details
Published in:Drug and alcohol dependence 2015-04, Vol.149, p.100-107
Main Authors: Tzeng, Nian-Sheng, Lu, Ru-Band, Yeh, Hui-Wen, Yeh, Yi-Wei, Huang, Chang-Chih, Yen, Che-Hung, Kuo, Shin-Chang, Chen, Chun-Yen, Chang, Hsin-An, Ho, Pei-Shen, Cheng, Serena, Shih, Mei-Chen, Huang, San-Yuan
Format: Article
Language:English
Subjects:
Adult
Amphetamine dependence
Amphetamine-Related Disorders - genetics
Amphetamine-Related Disorders - psychology
Asian Continental Ancestry Group
Case-Control Studies
Chinese men
DAT1 gene
Diagnostic and Statistical Manual of Mental Disorders
Dopamine Plasma Membrane Transport Proteins - genetics
Exploratory Behavior
Genetic Variation
Genotype
Haplotypes
Humans
Male
Middle Aged
Personality - genetics
Personality Tests
Personality trait
Polymorphism, Single Nucleotide
Psychiatry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • DAT1 gene was analyzed in patients with amphetamine dependence (AD), and different personality. • A weak association was found between the rs27072 polymorphism and development of AD. • The borderline associations were not evident in subsequent correction. • High harm avoidance and novelty seeking personality may be a risk factor for the development of AD. • DAT1 gene may not contribute to AD susceptibility and specific personality traits.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2015.01.030