Effect of Low-intensity Pulsed Ultrasound (LIPUS) with Different Frequency on Bone Defect Healing

Low-intensity pulsed ultrasound (LIPUS) is known to promote bone defect healing. The frequency of the LIPUS is known to influence directivity and depth of penetration, but the differences on bone healing remains unknown. This study was to investigate the effect of LIPUS with different frequencies on...

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Bibliographic Details
Published in:Journal of Hard Tissue Biology 2015, Vol.24(2), pp.189-198
Main Authors: Monden, Kazuya, Sasaki, Hodaka, Yoshinari, Masao, Yajima, Yasutomo
Format: Article
Language:English
Subjects:
Bone healing
Dental implant
Frequency
Low-intensity pulsed ultrasoud
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Summary:Low-intensity pulsed ultrasound (LIPUS) is known to promote bone defect healing. The frequency of the LIPUS is known to influence directivity and depth of penetration, but the differences on bone healing remains unknown. This study was to investigate the effect of LIPUS with different frequencies on bone defect healing. Bone defects of 1.6 mm in diameter were created in femurs of ten-week-old male Long-Evans rats (n=36). Experimetal groups were exposed LIPUS (intensity: 30 mW/cm2, burst width: 200 μs, time: 15 min/day) and divided into a low frequency (LF, 1.5 MHz) group and a high frequency (HF, 3.0 MHz) group. Non-exposed LIPUS group were used as control. After 3, 5, 7, and 10 days, femurs were removed and radiological, histomorphological and molecular biological evaluations were conducted. Micro-CT images showed that the depression in cortical bone was reduced in LF and HF groups. 3D bone morphological analysis at 10 days revealed that LIPUS increased cortical bone volume / tissue volume (BV/TV) and decreased BV/TV in the lower layer of cancellous bone (P
ISSN:1341-7649
1880-828X
DOI:10.2485/jhtb.24.189