Risk Factors for Re-recurrence After First Reoperative Surgery for Locoregional Recurrent/Persistent Papillary Thyroid Carcinoma

Background Papillary thyroid carcinoma (PTC) is generally an indolent tumor indicative of favorable prognosis. However, post-treatment recurrences may be problematic, and management strategies for recurrent disease have not been established. This study investigated risk factors associated with re-re...

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Bibliographic Details
Published in:World journal of surgery 2015-08, Vol.39 (8), p.1943-1950
Main Authors: Lee, Hwan Seo, Roh, Jong-Lyel, Gong, Gyungyup, Cho, Kyung-Ja, Choi, Seung-Ho, Nam, Soon Yuhl, Kim, Sang Yoon
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma - pathology
Carcinoma - secondary
Carcinoma - surgery
Carcinoma, Papillary
Cardiac Surgery
Chronic Disease
Female
Follow-Up Studies
General Surgery
Humans
Hypoparathyroidism - etiology
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - etiology
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Original Scientific Report
Papillary Thyroid Carcinoma
Parathyroid Gland
Postoperative Complications
Prognosis
Recurrent Laryngeal Nerve
Remission Induction
Reoperation - adverse effects
Reoperation - methods
Retrospective Studies
Risk Factors
Surgery
Thoracic Surgery
Thyroglobulin - blood
Thyroid Cancer, Papillary
Thyroid Neoplasms - pathology
Thyroid Neoplasms - secondary
Thyroid Neoplasms - surgery
Thyroid Remnant
Thyroidectomy - adverse effects
Thyroidectomy - methods
Vascular Surgery
Vocal Cord Paralysis
Vocal Cord Paralysis - etiology
Young Adult
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Summary:Background Papillary thyroid carcinoma (PTC) is generally an indolent tumor indicative of favorable prognosis. However, post-treatment recurrences may be problematic, and management strategies for recurrent disease have not been established. This study investigated risk factors associated with re-recurrence of PTC after reoperative surgery. Materials and methods This study included 151 patients with pathologically confirmed recurrent/persistent PTC who underwent reoperation. Clinical factors, operative and pathologic findings, serum thyroglobulin levels, postoperative complications, and recurrences were examined. Univariate and multivariate analyses were performed to identify factors associated with re-recurrence-free survival (RFS) after reoperative surgery. Results Recurrent tumors were found in thyroid remnants or previous resection bed ( n  = 28), central nodes ( n  = 48), and lateral neck nodes ( n  = 102). Biochemical complete remission (stimulated thyroglobulin
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-015-3052-2