GDF11 and the Mythical Fountain of Youth

Identifying candidates that rejuvenate aged muscle stem cells is an important strategy toward developing therapies to treat age-related diseases. In this issue, Egerman et al. (2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a pot...

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Bibliographic Details
Published in:Cell metabolism 2015-07, Vol.22 (1), p.54-56
Main Authors: Brun, Caroline E., Rudnicki, Michael A.
Format: Article
Language:English
Subjects:
Animals
Bone Morphogenetic Proteins - metabolism
Growth Differentiation Factors - metabolism
Humans
Muscle, Skeletal - physiology
Regeneration
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Summary:Identifying candidates that rejuvenate aged muscle stem cells is an important strategy toward developing therapies to treat age-related diseases. In this issue, Egerman et al. (2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration. Identifying candidates that rejuvenate aged muscle stem cells is an important strategy toward developing therapies to treat age-related diseases. In this issue, Egerman et al. re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2015.05.009