Stimulation of rat spleen cells by staphylococcal enterotoxins

There is much interest in staphylococcal enterotoxins as T cell mitogens in humans, mice and rabbits. Rat spleen cells were shown to proliferate in response to staphylococcal enterotoxins A and B and toxic shock syndrome toxin‐1 at concentrations (5 to 500 ng ml−1) which also stimulate mouse spleen...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 1993-08, Vol.7 (2), p.169-174
Main Authors: Holbrook, M.R., Young, K.E., Gibbon, L.G., Webster, C.A., Tranter, H.S., Arbuthnott, J.P., Todd, I.
Format: Article
Language:English
Subjects:
Animals
Bacterial Toxins
Biological and medical sciences
Cells, Cultured
Enterotoxins - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Lymphocyte Activation
Modulation of the immune response (stimulation, suppression)
Rat spleen cell
Rats
Rats, Inbred Lew
Rats, Wistar
Staphylococcal enterotoxin
Staphylococcus
Staphylococcus aureus - immunology
Superantigen
Superantigens - immunology
T lymphocyte stimulation
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
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Summary:There is much interest in staphylococcal enterotoxins as T cell mitogens in humans, mice and rabbits. Rat spleen cells were shown to proliferate in response to staphylococcal enterotoxins A and B and toxic shock syndrome toxin‐1 at concentrations (5 to 500 ng ml−1) which also stimulate mouse spleen cells. The proliferative response to all these enterotoxins was inhibitted by cyclosporin A, indicating the response to be predominantly that of T cells. These results indicate that the rat provides another convenient model for the analysis of T cell responses to enterotoxins.
ISSN:0928-8244
1574-695X
DOI:10.1111/j.1574-695X.1993.tb00396.x