Ischemia-modified albumin levels in overt and subclinical hypothyroidism

Background Free radical-mediated oxidative stress (OS) has been implicated in the pathogenesis of thyroid disorders. The ischemia-modified albumin (IMA) has been proposed as a marker of protein oxidative damage, which has been found to reflect hypoxic stress. Aim Our aim was to evaluate IMA, malondi...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2015-08, Vol.38 (8), p.885-890
Main Authors: Reddy, S. V., Suchitra, M. M., Pradeep, V., Alok, S., Suresh, V., Bitla, A. R., Srinivasa Rao, P. V. L. N.
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Case-Control Studies
Endocrinology
Female
Humans
Hypothyroidism - blood
Hypothyroidism - diagnosis
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Oxidative Stress - physiology
Serum Albumin
Serum Albumin, Human
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Summary:Background Free radical-mediated oxidative stress (OS) has been implicated in the pathogenesis of thyroid disorders. The ischemia-modified albumin (IMA) has been proposed as a marker of protein oxidative damage, which has been found to reflect hypoxic stress. Aim Our aim was to evaluate IMA, malondialdehyde (MDA), and reduced glutathione (GSH) levels in patients with overt hypothyroidism (OHT) and subclinical hypothyroidism (SHT) in comparison to euthyroid controls. Subjects and methods Albumin, IMA, IMA/albumin ratio, MDA, GSH, total cholesterol (TC), triglycerides (TG), HDL-Cholesterol were assessed in 105 subjects grouped into OHT, SHT patients, and euthyroid controls with 35 subjects in each group. Results MDA and IMA levels were significantly elevated while the GSH concentrations were significantly lower in OHT and SHT patients compared to controls ( p  
ISSN:1720-8386
1720-8386
DOI:10.1007/s40618-015-0283-x