Apoptosis level in developing T cells in the thymus

A study investigated the apoptosis level in developing T cells in the thymus. Results indicate that the level of apoptosis of CD4+CD8+ thymocytes in the thymus of adult intact mice does not exceed 5%, which contradicts the existing hypothesis about the maturation and differentiation of T cells.The p...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2015-05, Vol.462 (1), p.163-165
Main Authors: Starskaya, I. S., Kudryavtsev, I. V., Guselnikova, V. V., Serebriakova, M. K., Polevshchikov, A. V.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Cell Count
Cell Proliferation
Flow Cytometry
Immune system
Life Sciences
Male
Mice
T cell receptors
T-Lymphocytes - cytology
Thymus Gland - immunology
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Summary:A study investigated the apoptosis level in developing T cells in the thymus. Results indicate that the level of apoptosis of CD4+CD8+ thymocytes in the thymus of adult intact mice does not exceed 5%, which contradicts the existing hypothesis about the maturation and differentiation of T cells.The percentage of apoptotic cells in the medullary zone of the thymus is much higher than in the cortex, which indirectly indicates the selection processes pri marily in the medullary zone of the thymus, containing mature thymocytes CD4+CD8 and CD4CD8+.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672915030060