Telomerase activity in peripheral blood mononuclear cells as a universal scale for quantitative measurement of telomerase activation on the example of liver diseases

The aim of our study was to develop a universal scale for telomerase activity values and to use it to eval uate telomerase activity in liver cells in various pathol ogies (hepatoblastoma, HCC, nonviral and nonalco holic cirrhosis, and giant mesenchymal hamartoma). We have found that, in four of six...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2015-05, Vol.462 (1), p.172-175
Main Authors: Skvortsov, D. A., Ezhova, M. A., Lourie, Y. E., Metelin, A. V., Strazhesko, I. D., Dudinskaya, E. N., Kalinina, M. A., Zvereva, M. E., Dontsova, O. A., Kim, E. F.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Blood
Enzyme Activation
Enzyme Assays - standards
HEK293 Cells
Humans
Leukocytes, Mononuclear - enzymology
Life Sciences
Liver diseases
Liver Diseases - blood
Liver Diseases - enzymology
Liver Diseases - therapy
Liver Transplantation
Telomerase
Telomerase - metabolism
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Summary:The aim of our study was to develop a universal scale for telomerase activity values and to use it to eval uate telomerase activity in liver cells in various pathol ogies (hepatoblastoma, HCC, nonviral and nonalco holic cirrhosis, and giant mesenchymal hamartoma). We have found that, in four of six hepatoblastoma specimens, telomerase activity was increased compared to the normal tissue. A high telomerase activity was found in one of six hepatoblastoma specimens, whereas in the HCC specimen and both specimens from patients with cirrhoses of nonvi ral and nonalcoholic etiology, the telomerase activity was low.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672915030096