Urocortin 2 in cardiovascular health and disease

•Urocortin (Ucn)-2 regulates cardiac function.•Ucn-2/CRH-R2 system activation promotes a consistent relaxation of the vessels.•Animal studies have shown beneficial therapeutic effects of Ucn-2 in heart failure.•Therapeutic benefits of Ucn-2 have also been shown in patients with heart failure.•Ucn-2...

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Bibliographic Details
Published in:Drug discovery today 2015-07, Vol.20 (7), p.906-914
Main Authors: Adão, Rui, Santos-Ribeiro, Diana, Rademaker, Miriam T., Leite-Moreira, Adelino F., Brás-Silva, Carmen
Format: Article
Language:English
Subjects:
Animals
Cardiovascular Agents - chemistry
Cardiovascular Agents - therapeutic use
Cardiovascular System - drug effects
Cardiovascular System - metabolism
Cardiovascular System - physiopathology
Chronic Disease
Heart Failure - drug therapy
Heart Failure - metabolism
Heart Failure - physiopathology
Humans
Protein Conformation
Receptors, Corticotropin-Releasing Hormone - agonists
Receptors, Corticotropin-Releasing Hormone - metabolism
Signal Transduction - drug effects
Structure-Activity Relationship
Urocortins - chemistry
Urocortins - metabolism
Urocortins - therapeutic use
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Summary:•Urocortin (Ucn)-2 regulates cardiac function.•Ucn-2/CRH-R2 system activation promotes a consistent relaxation of the vessels.•Animal studies have shown beneficial therapeutic effects of Ucn-2 in heart failure.•Therapeutic benefits of Ucn-2 have also been shown in patients with heart failure.•Ucn-2 is emerging as a promising therapeutic option for cardiovascular diseases. Urocortin (Ucn)-2 – corticotropin-releasing hormone receptor 2 signaling has favorable effects in the cardiovascular system, including coronary vasodilatation, with increased coronary blood flow and conductance and augmented cardiac contractility and output, as well as protection against ischemia/reperfusion injury. Indeed, several animal studies have confirmed the salutary therapeutic effects of Ucn-2 in chronic heart failure, with improvements in cardiac performance and animal survival. In addition, recent clinical trials have demonstrated the benefits of Ucn-2 in patients with stable chronic heart failure on optimal medical therapy.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2015.02.012