Insights into Myeloid-Derived Suppressor Cells in Inflammatory Diseases

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells involved in immune regulation. This population subdivides into granulocytic MDSCs and monocytic MDSCs, which regulate immune responses via the production of various molecules including reactive oxygen species, nitric ox...

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Bibliographic Details
Published in:Archivum Immunologiae et Therapiae Experimentalis 2015-08, Vol.63 (4), p.269-285
Main Authors: Kwak, Yewon, Kim, Hye-Eun, Park, Sung Gyoo
Format: Article
Language:English
Subjects:
Animals
Arginase - metabolism
Arthritis - immunology
Asthma - immunology
Autoimmunity
Biomedical and Life Sciences
Biomedicine
Dendritic Cells - immunology
Hepatitis, Autoimmune - immunology
Humans
Immune System - physiology
Immune Tolerance
Immunology
Inflammation - metabolism
Inflammatory Bowel Diseases - immunology
Killer Cells, Natural - immunology
Lymphocyte Activation
Multiple Sclerosis - immunology
Myeloid Cells - immunology
Neoplasms - immunology
Nitric Oxide Synthase Type II - metabolism
Peroxynitrous Acid
Pharmacology/Toxicology
Phenotype
Prognosis
Reactive Oxygen Species - metabolism
Review
T-Lymphocytes, Regulatory - immunology
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Summary:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells involved in immune regulation. This population subdivides into granulocytic MDSCs and monocytic MDSCs, which regulate immune responses via the production of various molecules including reactive oxygen species, nitric oxide, arginase-1, interleukin-10, and transforming growth factor-β. Most studies of MDSCs focused on their role in tumors. MDSCs protect tumor cells from immune responses, and thus the frequency of MDSCs associates with poor prognosis. Many recent studies reported an important role for MDSCs in inflammatory diseases via the regulation of immune cells. In addition, the utilization of MDSCs by infectious pathogens suggests an immune evasion mechanism. Thus, MDSCs are important immune regulators in inflammatory diseases, as well as in tumors. This review focuses on the role of MDSCs in the regulation of inflammation in non-tumor settings.
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-015-0342-1